Water-mediated electrostatic interactions between ions, molecules, and interfaces are crucial in ion adsorption, ion transport, surface chemical reactions, to mention a few. These physicochemical processes occur in technological applications such as water desalination, electrochemical energy storage and harvesting, and characterization of biomolecules. Therefore, understanding how water mediates electrostatic interactions via the orientation of its dipoles is of paramount importance. We investigate the effective interaction between two oppositely charged ions in different positions in water confined between two graphene surfaces. The goal is to gain fundamental understanding of ionic interactions in confinement. The study is performed using molecular dynamics simulations and the prediction of the water structure is in agreement with x-ray reflectivity experiments.